Gluconeogenesis

Links

lactate dehydrogenase

alanine transaminase

Pyruvate

pyruvato carboxilase

Acetyl-CoA

malate dehydrogenase (mitochondria)l

pep carboxylinase (mitochondra)

Malate

Phosphoenolpyruvate

malate dehydrogenase (cytoplasm)

pep carboxykinase (cytoplasm)

Phosphoenolpyruvate

2-phosphoglycerate

phosphoglycerate mutase

3-phosphoglycerate

phosphoglycerate kinase

1,3-biphosphoglycerate

glyceraldehyde- 3-P- dehydrogenase

Glyceraldehyde-3-P

Dihydroxyacetone-P

triose fosfato isomerase

+

fructose bi-P aldolase

Fructose-1,6-biphosphate

hexose diphosphatase

Fructose 2,6BiP, AMP

Fructose-6-phosphate

glucose-6-P isomerase

Glucose-6-phosphate

glucose-6 phosphatase

a-D-glucose

Overview:

2 Pyruvate + 4ATP + 2GTP + 2NADH + 2H₂O

Glucose + 4ADP + 2GDP + 6Pi + 2NAD⁺ + 2H⁺

Carbohydrate Metabolism

Gluconeogenesis

reciprocal regulation of gluconeogenesis and glycolysis

reciproc regulation of gluconeogenesis and glycolysis

gluconato, glucose-6-P, ATP, PEP

3-P-glycerate

NADH + H⁺

GDP + Pi

ADP + Pi

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