Enzyme - EC 2.6.1.2 - Alanine aminotransferase
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The tridimensional structure of this enzyme has not been resolved yet.
EC
2.6.1.2
Official Name
Alanine aminotransferase
Alternative Name(s)
Glutamic-pyruvic transaminase
Glutamic-alanine transaminase
Glutamic-alanine transaminase
Class
2.Transferases
6.Transferring nitrogenous groups
1.Transaminases
6.Transferring nitrogenous groups
1.Transaminases
Catalysed reaction
L-alanine + 2-oxoglutarate
pyruvate
+ L-glutamate
pyruvate
+ L-glutamateSubstrates
L-Alanine
2-Oxoglutarate
(S)-2-Aminobutanoate
2-Oxoglutarate
(S)-2-Aminobutanoate
Products
Pyruvate
L-Glutamate
2-Oxobutanoate
L-Glutamate
2-Oxobutanoate
Cofactor(s)
Pyridoxal-P
Metabolic Pathways
Other comments
2-aminobutanoate acts slowly instead of alanine.
Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (glucose-alanine cylce).