Pyruvate
amino acid      2-oxoacid

Alanine

alanine transaminase
sulfonyl-ureas, imidazol-inones
ThPP
2(a-hydroxy-ethyl)-ThPP
2(a-hydroxy-ethyl)-ThPP
2-oxobutyrate
acetolactate synthase

2-acetolactate


2-aceto-2-hydroxy-butyrate
Leucine, Valine, Isoleucine
(R)-3-Hidroxi-3-metil-2-cetobutanoato
        ketol-acid reducto isomerase                  


(S)-2-hydroxy-3-methyl-3-oxopentanoate
             ketol-acid reducto isomerase                    
NADPH + H+
NADP+
NADPH + H+


2-3-dihydroxy-isovalerate
NADP+


2-3-dihydroxy-3-methyl-valerate
Leucine, Valine, Isoleucine
H2O

2-oxo-isovalerate

2-isopropylmalate synthase
            dihydroxy acid dehydratase                       
H2O

2-isopropyl-malate
Glutamate


2-oxo-3-methylvalerate
2-oxoglutarate
isopropyl malate isomerase

Valine
2-oxo-3-methyl-valerate
branched-chain amino acid transaminase 

3-isopropylmalate
Glutamate
2-oxoglutarate

Isoleucine
NAD+
3-isopropyl malate dehydrogenase
NADH + H+
CO2

2-Oxoisocaproate
branched-chain amino acid transaminase
Glutamate
2-oxoglutarate

Leucine
Leuciny
Overview:
Amino acids synthesis
Alanine, Isoleucine, Valine e Leucine
IsoleucineValine
ThPP
3-carboxy-3-hydroxyisocaproate
Leucina
caproate
Acetyl-CoA       CoA
2-oxobutyrate
Pyruvate
Isoleucine
Valine
Leucine
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