Enzyme - EC
1.1.1.86 Ketol-acid reductoisomerase
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EC
1.1.1.86
Official
Name
Ketol-acid reductoisomerase
Alternative
name(s)
Dihydroxyisovalerate dehydrogenase
(isomerizing)
Acetohydroxy acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Acetohydroxy acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Class
1.Oxidoreductases
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
(R)-2,3-dihydroxy-3-methylbutanoate
+ NADP+ 
(S)-2-hydroxy-2-methyl-3-oxobutanoate
+ NADPH
(S)-2-hydroxy-2-methyl-3-oxobutanoate
+ NADPHSubstrates
(R)-2,3-Dihydroxy-3-methylbutanoate
2-Aceto-2-hydroxybutanoate
NADP+
2-Aceto-2-hydroxybutanoate
NADP+
Products
(S)-2-Hydroxy-2-methyl-3-oxobutanoate
2,3-Dihydroxy-3-methylpentanoate
NADPH
2,3-Dihydroxy-3-methylpentanoate
NADPH
Metabolic Pathways
Other
comments
Also catalyses the reduction of 2-aceto-2-hydroxybutanoate to 2,3-dihydroxy-3-methylpentanoate (EC 1.1.1.89).