Pyruvate
amino acid      2-oxoacid

alanine

alanine transaminase
sulfonyl-ureas, imidazol-inones
ThPP
2(a-hydroxy-ethyl)-ThPP
2(a-hydroxy-ethyl)-ThPP

2-oxobutyrate
acetolactate synthase

2-acetolactate


2-aceto-2-hydroxy-butyrate
Leucine, Valine, Isoleucine
(R)-3-Hidroxi-3-metil-2-cetobutanoato
          ketol-acid reducto isomerase                     
(S)-2-hydroxy-3-methyl-3-oxopentanoate
           ketol-acid reducto isomerase                    
NADPH + H+
NADP+


2-3-dihydroxy-isovalerate
NADP+


2-3-dihydroxy-3-methyl-valerate
Leucine, Valine, Isoleucine
H2O

2-oxo-isovalerate

2-isopropylmalate synthase
            dihydroxy acid dehydratase                      
H2O

2-isopropyl-malate
Glutamate

2-oxo-3-methylvalerate
2-oxoglutarate
isopropyl malate isomerase

Valine
2-oxo-3-methyl-valerate
branched-chain amino acid transaminase 

3-isopropylmalate
Glutamate
2-oxoglutarate

Isoleucine
NAD+
3-isopropyl malate dehydrogenase
NADH + H+
CO2
2-Oxoisocaproate
branched-chain amino acid transaminase
Glutamate
2-oxoglutarate

Leucine
Leucine
Overview:
Amino acids synthesis
Alanine, Isoleucine, Valine e Leucine
IsoleucineValine
ThPP
3-carboxy-3-hydroxyisocaproate
Leucina
caproate
Acetyl-CoA       CoA
NADPH + H+
2-oxobutyrate
Isoleucine
Pyruvate
Valine
Leucine
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