Evolutionary related to 6-phosphogluconate dehydratase (EC 4.2.1.12) which catalyzes the first step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho- D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. Both enzymes are proteins of about 600 amino acid residues. Two highly conserved regions were selected as signature patterns. The first pattern is located in the N-terminal part and contains a cysteine that could be involved in the binding of a 2Fe-2S iron-sulfur cluster. The second pattern is located in the C-terminal half.
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