Enzyme - EC
1.1.1.85 - 3-isopropylmalate dehydrogenase
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EC
1.1.1.85
Official
Name
3-isopropylmalate dehydrogenase
Alternative
name(s)
Beta-isopropylmalate
dehydrogenase
Beta-IPM dehydrogenase
IMDH
Beta-IPM dehydrogenase
IMDH
Class
1.Oxidoreductases
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
3-Carboxy-2-hydroxy-4-methylpentanoate
+ NAD+
3-Carboxy-4-methyl-2-oxopentanoate
+ NADH
3-Carboxy-4-methyl-2-oxopentanoate
+ NADHSubstrates
3-Isopropylmalate
NAD+
3-Carboxy-2-hydroxy-4-methylpentanoate
NAD+
3-Carboxy-2-hydroxy-4-methylpentanoate
Products
NADH
3-Carboxy-4-methyl-2-oxopentanoate
4-Methyl-2-oxopentanoate
3-Carboxy-4-methyl-2-oxopentanoate
4-Methyl-2-oxopentanoate
Metabolic Pathways
Other
comments
The product decarboxylates to 4-methyl-2-oxopentanoate.
Related to isocitrate dehydrogenase (EC 1.1.1.41).