Amino acids catabolism
Threonine, Glycine, Tryptophan, Alanine, Cysteine and Serine
to Acetyl-Coa (by Pyruvate)
Threonine

Tryptophan
threonine aldolase
tryptophan 2,3-dioxygenase
O2
tryptophan, kynurenine, steroids
tryptophan, NADPH

Acetaldehyde

Glicine

L-formylkynurenine

cysteine
N5,N10- methylene-THF, H2O
glycine hydroxymethyl transferase
cysteine dioxygenase
formamidase
2O2, 2NADH+2H
H2O
anthranilate
2NAD+ + 2H2O
HCOO- (formate)
THF

L-kynurenine

Serine

3-Sulfino-L-alanine
aspartate transaminase
kynureninase

NH3+

H2O
Glutamate
tryptophan
2-oxoglutarate
alanine transaminase
corticoids

Alanine

Pyruvate

3-Sulfopyruvate
non-enzimatic ?
2-oxoglutarate  Glutamate
H2SO3
+
pyruvate dehydrogenase
NAD+, CoA-SH
NADH + H+, CO2

Acetyl-CoA

3-hydroxy-anthranilate
serine dehydratase
regulation

3-hydroxy-L-kynurenine
NADPH + H+, O2
NADP+, H2O
kynurenine 3-monooxygenase
5-formyl; 5-methyl-THF; methionine, SAM
H2O

high protein diet, ADP, AMP, A-3,5-MP

high carbohydrate diet


Pyruvate
NH3+, homocysteine
cystathionine b-lyase
H2O
H2O
DHTML JavaScript Menu Courtesy of Milonic.com