Enzyme - EC 4.4.1.8 - Cystathionine b-lyase

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EC
  
4.4.1.8
Official Name
Cystathionine b-lyase
Alternative Name(s)
b-cystathionase
b C-S lyase
Cysteine lyase
Cystine lyase
Class
4.Lyases
4.Carbon-sulfur lyases
Catalysed reaction
cystathionine + H2O L-homocysteine + NH3+ pyruvate
Substrates
cystathionine
L-cistina
H2O
Products
 L-homocysteine
NH3
pyruvate
cysteine persulfide
Cofactor(s)
pyridoxal-P
Metabolic Pathways
Catabolism of threonine, tryptophan, glycine, alanine, cysteine and serine (3D)
Synthesis of aspartate, lysine, threonine and methionine (3D)
Selenoamino acid metabolism (Kyoto University)
Nitrogen metabolism (Kyoto University)
Sulfur metabolism (Kyoto University)
Other comments

The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds.

Related to others Cys/Met metabolism enzymes pyridoxal-phosphate.

Belongs to the group of aminotransferases class-II pyridoxal-phosphate.

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