Amino acids catabolism
Threonine, Glycine, Tryptophan, Alanine, Cysteine and Serine
to Acetyl-Coa (by Pyruvate)

Threonine

Tryptophan
threonine aldolase
tryptophan 2,3-dioxygenase
O2
tryptophan, kynurenine, steroids
tryptophan, NADPH

Acetaldehyde

Glycine

L-formylkynurenine

Cysteine
N5,N10- methylene-THF, H2O
glycine hydroxymethyl transferase
cysteine dioxygenase
formamidase
2O2, 2NADH+2H
H2O
anthranilate
2NAD+ + 2H2O
HCOO- (formate)
THF

L-kynurenine

Serine

3-Sulfino-L-alanine
aspartate transaminase
kynureninase
H2O

NH4

H2O
2-oxoglutarate
tryptophan
Glutamate
alanine transaminase
corticoids

Alanine

Pyruvate

3-Sulfopyruvate
non-enzimatic
2-oxoglutarato  Glutamate
H2SO3
+
pyruvate dehydrogenase
CoA-SH
CO2

Acetyl-CoA

3-hydroxy-anthranilate
L-serine ammonia-lyase
regulation
3-hydroxy-L-kynurenine
kynurenine 3-monooxygenase
NADPH + H+, O2
NADP+, H2O
5-formyl; 5-methyl-THF; methionine, SAM

high protein diet, ADP, AMP, A-3,5-MP

high carbohydrate diet

H2O
cystathionine b-lyase
NH3+, homocysteine

Pyruvate
H2O
NAD+
NADH + H+
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