Enzyme - EC
1.13.11.11 - Tryptophan 2,3-dioxygenase
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The tridimensional structure
of this enzyme has not been resolved yet.
EC
1.13.11.11
Official
Name
Tryptophan 2,3-dioxygenase
Alternative
name(s)
Tryptophan pyrrolase
Tryptophanase
Tryptophan oxygenase
Tryptamin 2,3-dioxygenase
Tryptophan peroxidase
Tryptophanase
Tryptophan oxygenase
Tryptamin 2,3-dioxygenase
Tryptophan peroxidase
Class
1.Oxidoreductases
13.Acting on single donors with incorporation of molecular oxygen (oxygenases)
11.With incorporation of two atoms of oxygen
13.Acting on single donors with incorporation of molecular oxygen (oxygenases)
11.With incorporation of two atoms of oxygen
Reaction
catalysed
L-Tryptophan
+ O2 
L-Formylkynurenine
L-FormylkynurenineSubstrates
L-Tryptophan
O2
Tryptamine
D-Tryptophan
5-Hydroxytryptophan
Serotonin
O2
Tryptamine
D-Tryptophan
5-Hydroxytryptophan
Serotonin
Products
L-Formylkynurenine
Cofactor(s)
Protoheme
Metabolic
Pathways
Other
comments
A protohemoprotein. Broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.