Acetyl-CoA

Acetoacetyl-CoA

3-Hydroxybutanoyl-CoA

Crotonyl-CoA

Glutaconyl-CoA

Glutaryl-CoA

2-oxoadipate

NADH/ NADPH + H+

NAD+/ NADP+ + NH₃⁺

2-aminoadipate

2-Aminomuconate

NADH/ NADPH + H+

NAD+/ NADP+

H2O, NAD+

2-Aminoadipate 6-semialdehyde

NADH + H+

2-aminomuconate semialdehyde

NAD⁺ + H₂O

NADH; Glutamate; H₂O

Saccharopine

2-amino-3-carboxymuconate semialdehyde

NADH/ NADPH + H⁺, 2-oxoglutarate

NAD+/ NADP+, H₂O

Lysine

Alanine

3-hydroxy-anthranilate

3-hydroxy-L-kynurenine

NADPH + H+

L-kynurenine

L-formylkynurenine

Tryptophan

Overview:

Tryptophan + 3O₂ + 3H₂O + 2NAD(P)H + 3NAD⁺ + FAD + CoA-SH ---> Acetyl-CoA + NAD(P)⁺ + NADH + FADH₂ + 4CO₂
Lisina +2-oxoglutarate +2NAD⁺ + NAD(P)⁺ + FAD + 2H₂O ---> Acetyl-CoA +Glutamate +2NADH +NAD(P)H + FADH₂ + 2CO₂

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