Tryptophan and lysine oxidation

Links

2

Acetoacetyl-CoA

3-hydroxyacyl-CoA dehydrogenase

NADH + H+

3-Hydroxybutanoyl-CoA

enoyl-CoA hydratase

fatty acid oxidation

glutaryl-CoA dehydrogenase

glutaryl-CoA dehydrogenase

oxoglutarate dehydrogenase

NADH + H+

NADH/NADPH + H+

2-aminoadipate transaminase

NAD+/NADP+ + NH₃⁺

2-Aminomuconate

NADH/NADPH + H+

L-aminoadipate-semialdehyde dehydrogenase

aminomuconate-semialdehyde dehydrogenase

2-Aminoadipate 6-semialdehyde

NADH + H+

2-aminomuconate semialdehyde

NAD⁺ + H₂O

saccharopine dehydrogenase (NAD, L-glutamate-forming)

NADH + H+, Glutamate, H₂O

aminocarboxymuconate-semialdehyde decarboxylase

2-amino-3-carboxymuconate semialdehyde

NADH/NADPH + H+, 2-oxoglutarato

saccharopine dehydrogenase (NAD, L-lysine-forming)

NADP+/NAD+, H₂O

O₂

3-hydroxyanthranilate 3,4-dioxygenase

aminophenols, amino-benzoate

+

3-hydroxy-anthranilate

tryptophan

3-hydroxy-L-kynurenine

O₂

kynurenine 3-monooxygenase

Cinurenino

anthranilate

L-formylkynurenine

O₂

tryptophan 2,3-dioxygenase

tryptophan, kynurenine, steroids

tryptophan, NADPH

Overview:

Tryptophan + 3O₂ + 3H₂O + 2NAD(P)H + 3NAD⁺ + FAD + CoA-SH ---> Acetyl-CoA + NAD(P)⁺ + NADH + FADH₂ + 4CO₂
Lisina +2-oxoglutarate +2NAD⁺ + NAD(P)⁺ + FAD + 2H₂O ---> Acetyl-CoA +Glutamate +2NADH +NAD(P)H + FADH₂ + 2CO₂

Amino acids catabolism
Tryptophan and Lysine
degradatiob to Acetyl-CoA

acetoacetyl-coa tyolase

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