Catabolism pathway :

L-Tryptophan
O2
tryptophan 2,3-dioxygenase

tryptophan, kynurenine, steroids

tryptophan, NADPH



N-formylkynurenine
H2O
formamidase
anthranilate
HCOO- (formate)

L-kynurenine
H2O
kinureninase
tryptophan

Alanine


3-hydroxyanthranilate
2-oxoglutarate
alanine transaminase
O2
hydroxyanthranilate oxygenase
amino-phenols,     amino-benzoate
glutamate
pyruvate


2-amino-3-carboxymuconate 6-semialdehyde (ACS)
CoA-SH
pyruvate dehydrogenase
CO2
aminocarboxymuconate-semialdehyde descarboxylase
NAD+
NADH, H+
CO2

acetyl-CoA


2-aminomuconate 6-semialdehyde

Leucine
NADH/NADPH + H+
dehydrogenase
2-oxoglutarate
branched-chain-amino-acid transaminase
3-(methylene-) cyclopropylalanine
NAD+/NADP+ + NH3+
glutamate

2-aminomuconate

2-Oxoisocaproate
NAD+, H2O
2-aminomuconate semialdehyde dehydrogenase
CoA-SH
oxoglutarate desidrogenasehy
2-oxoisovalerate, 2-oxo-3-methyl-valerate
NAD+
NADH, H+
NADH, H+
CO2

2-oxoadipate

isovaleryl-CoA
CoA-SH
oxoglutarate dehydrogenase
FAD+
acyl-CoA dehydrogenase
NAD+
NADH, H+
FADH2
CO2

glutaryl-CoA

3-methyl-crotonyl-CoA

Isoleucine
FAD
glutaryl-CoA dehydrogenase
HCO3-
methylcrotonyl-CoA carboxylase
2-oxoglutarate
branched-chain-amino-acid transaminase
ATP
FADH2
ADP + Pi
glutamate

glutaconyl-CoA

3-methyl-glutaconyl-CoA

3-Methyl-2-oxopentanoate
glutaryl-CoA dehydrogenase
H2O
3-methyl-glutaconyl-CoA hydratase
CoA-SH
oxoglutarate dehydrogenase
NAD+
HCO3-
NADH, H+
CO2

crotonyl-CoA

3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA)

2-Methylbutyryl-CoA
fatty acid oxidation
H2O
enoyl-CoA hydratase
HMG-CoA lyase
FAD+
acyl-coa dehydrogenase
FADH2

3-Hydroxybutanoyl-CoA

tiglyl-CoA
acetyl-CoA
NAD+
3-hydroxyacyl-CoA dehydrogenase

acetoacetate
H2O
enoyl-coa hydratase
NADH, H+

acetoacetyl-CoA
Succinyl-CoA

3-Hydroxy-2-methylbutyryl-CoA
CoA-SH
acetoacetyl-CoA thiolase
NAD+
3-hydroxyacy-CoA dehydrogenase
NADH, H+

acetyl-CoA
propionyl-CoA

2-Methylacetoacetyl-CoA
Isoleucine + 3-oxoglutarate +2CoA-SH +2NAD+ +FAD+ +H2O---> glutamate +CO2 +2NADH +FADH2 +H+ +Acetyl-CoA +propionyl-CoA
Propionyl-CoA +CO2 --->Succinyl-CoA


Leucine + 3-oxoglutarate +CoA-SH +NAD+ +FAD+ + ATP + H2O + CO2 ---> glutamate +acetoacetate +CO2 +NADH +FADH2 +H+ +acetyl-CoA +ADP +Pi +H2O
Acetoacetate +succinyl-CoA +CoA-SH--->Succinate +2Acetyl-CoA

L-Tryptophan +O2 +NADPH +H+ +H2O---> L-alanine +3-hydroxyanthranilate +NADP+ +H+ +formate +H2O
L-alanine + 3-oxoglutarate +CoA-SH +NAD+---> glutamate +CO2 +NADH +acetyl-CoA
3-hydroxyanthranilate +2CoA-SH +3NAD+ +NADPH---> 3CO2 +3NADH +3H+ +NADP +2H2O +NH4+ +2H+ +0,5O2 +2Acetyl-CoA
Overview:

              

Amino acids catabolism
Isoleucine, Leucine and Tryptophan
2
3-oxoacid-CoA transferase
acetyl-CoA acyltransferase
regulation
hydratase
H2O
Succinate
CoA
kynurenine monooxygenase
O2
NADPH + H+
NADP+
H2O


3-hydroxy-L-kynurenine
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