Enzyme - EC 4.1.3.4 - Hydroxymethylglutaryl-CoA lyase
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The tridimensional structure of this enzyme has not been resolved yet.
EC
4.1.3.4
Official Name
Hydroxymethylglutaryl-CoA lyase
Alternative Name(s)
3-hydroxy-3-methylglutarate-CoA lyase
HMG-CoA lyase
HMG-CoA lyase
Class
4.Lyases
1.Carbon-carbon lyases
3.Oxo-acid-lyases
1.Carbon-carbon lyases
3.Oxo-acid-lyases
Catalysed reaction
(S)-3-hydroxy-3-glutaryl-CoA 
acetyl-CoA
+ acetoacetate
acetyl-CoA
+ acetoacetateSubstrates
(S)-3-hydroxy-3-glutaryl-CoA
Products
acetoacetate
Metabolic Pathways
Other comments
In
vertebrates it is a mitochondrial enyme which is involved in ketogenesis and
in leucine catabolism. In some bacteria, such as Pseudomonas mevalonii,
it is involved in mevalonate catabolism. A cysteine has been shown to be required for the activity of the enzyme. The region around
this residue is perfectly conserved and is used as a signature pattern.