Enzyme - EC
1.3.99.3 - Acyl-CoA dehydrogenase
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EC
1.3.99.3
Official
Name
Acyl-CoA dehydrogenase
Alternative
name(s)
Medium-chain acyl-CoA dehydrogenase
Acyl dehydrogenase
Acyl dehydrogenase
Class
1.Oxidoreductases
3.Acting on the CH-CH group of donors
99.With other acceptors
3.Acting on the CH-CH group of donors
99.With other acceptors
Reaction
catalysed
acyl-CoA + ETF
2,3-dihydroacyl-CoA
+ reduced ETF
2,3-dihydroacyl-CoA
+ reduced ETFSubstrates
acyl-CoA
acceptor
2-methylpropanoyl-CoA
2-methylbutanoyl-CoA
3-methylbutanoyl-CoA
acceptor
2-methylpropanoyl-CoA
2-methylbutanoyl-CoA
3-methylbutanoyl-CoA
Products
2,3-Dehidroacyl-CoA
reduced acceptor
2-methylprop-2-enoyl-CoA
2-methylbut-2-enoyl-CoA
3-methylbut-2-enoyl-CoA
reduced acceptor
2-methylprop-2-enoyl-CoA
2-methylbut-2-enoyl-CoA
3-methylbut-2-enoyl-CoA
Cofactor
FAD
Metabolic
Pathways
Catabolism of polyunsaturated fatty acids (3D)
Catabolism of fatty acids (3D)
Catabolism of methionine, threonine, isoleucine and valine (3D)
Catabolism of isoleucine, leucine and tryptophan (3D - isoleucine, leucine)
b-Alanine metabolism (Kyoto University)
Propanoate metabolism (Kyoto University)
Catabolism of fatty acids (3D)
Catabolism of methionine, threonine, isoleucine and valine (3D)
Catabolism of isoleucine, leucine and tryptophan (3D - isoleucine, leucine)
b-Alanine metabolism (Kyoto University)
Propanoate metabolism (Kyoto University)
Other
comments
A flavoprotein; forms with another flavoprotein ('electron- -transferring flavoprotein') and EC 1.5.5.1 a system reducing ubiquinone and other acceptors.
Belongs to the acyl-Coa dehydrogenases family.