Degradation pathways :

Valine

Isoleucine

Methionine
2-oxoglutarate
branched-chain-amino-acid transaminase
2-oxo-3-methyl-valerate
ATP
methionine adenosyltransferase
Pi, PPi, S-Adenosyl Methionine
glutamate
PPi

2-Oxoisovalerate

2-Oxo-3-methylvalerate

S - Adenosyl Methionine
CoA
oxoglutarate dehydrogenase
Cytosine (DNA)
DNA (cytosine-5-)-methyltransferase
S-Adenosyl homocysteine
NAD+
NADH + H+
DNA containing 5-methylcytosine
CO2

Isobutyryl-CoA

2-Methyl-butanoyl-CoA

S-Adenosyl Homocysteine
FAD
acyl- CoA dehydrogenase
H2O
Adenosine
FADH2

Methacrylyl-CoA

Tiglyl-CoA

Homocysteine
H2O
enoyl CoA hydratase
Serine
cystathionine b-synthase
ADP, AMP
H2O

3-Hydroxyisobutyryl-CoA


3-Hydroxy-2-methylbutyryl-CoA

Cystathionine
H2O
3-hydroxyisobutyryl-CoA hydrolase
NAD+
3-hydroxyacyl-CoA dehydrogenase
H2O
cystathionine g-lyase

Threonine
CoA
NADH + H+
cysteine, NH4+
3-Hydroxyisobutyrate

2-Methyl-3-acetoacetyl-CoA

2-oxobutanoate
treonina desidratase

AMP, ADP, valine

isoleucine, ATP

NAD+
3-hydroxyisobutyrate dehydrogenase
CoA
Acetyl-CoA
Isoleucine synthesis
NADH + H+

(S)-Methylmalonate semialdehyde


Propionyl - CoA

CO2 (HCO3-), ATP

propionyl-CoA carboxylase

(S)-Methyl-Malonyl-CoA
methylmalonyl-CoA epimerase

(R)-Methyl-Malonyl-CoA
methylmalonyl-CoA mutase

Succinyl-CoA
Homocysteine    Methionine
2-oxobutanoate Threonine
Isoleucine    Propionyl-CoA    Valine
Succinyl-CoA

Amino acids catabolism
Methionine, Threonine, Valine and Isoleucine
to Succinyl-CoA

                 

Overview:

CoA, NAD+

NADH + H+, CO2

methylmalonate-semialdehyde dehydrogenase
acetyl-CoA acyltransferase
adenosylhomocysteinase
NH4+
ADP + Pi
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