Enzyme - EC 4.4.1.1 - Cystathionine g-lyase

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EC
  
4.4.1.1
Official Name
Cystathionine g-lyase
Alternative Name(s)
Homoserine deaminase
Homoserine dehydratase
g-cystathionase
Cystine desulfhydrase
Cysteine desulfhydrase
Cystathionase
Cystathioninase
Class
4.Lyases
4.Carbon-sulfur lyases
Catalysed reaction
L-cystathionine + H2O L-cysteine + NH3 + 2-oxobutanoate
Substrates
L-Cystathionine
L-Homoserine
L-Cystine
L-Cysteine
H2O
Products
 L-Cysteine
2-Oxobutanoate
Thiocysteine
Pyruvate
H2S
NH3
Cofactor(s)
pyridoxal-P
Metabolic Pathways
Catabolism of methionine, threonine, isoleucine and valine (3D)
Synthesis of cysteine, glycine and serine (3D)
Selenoamino acid metabolism (Kyoto University)
Nitrogen metabolism (Kyoto University)
Other comments

Also catalyzes elimination reactions of L-homoserine to form H2O, NH3 and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH3, and of L-cysteine producing pyruvate, NH3 and H2S.

Related to others Cys/Met metabolism enzymes pyridoxal-phosphate.

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