Degradation pathways :

Valine

Isoleucine

Methionine
2-oxoglutarate
branched-chain-amino-acid transaminase
2-oxo-3-methyl-valerate
ATP
methionine adenosyltransferase
Pi, PPi, S-Adenosyl Methionine
glutamate
PPi

2-Oxoisovalerate


2-Oxo-3-methylvalerate

S - Adenosyl Methionine
CoA
oxoglutarate dehydrogenase
Cytosine (DNA)
DNA (cytosine-5-)-methyltransferase
S-Adenosyl homocysteine
NAD+
NADH + H+
DNA containing 5-methylcytosine
CO2

Isobutiryl-CoA

2-Methyl-butanoyl-CoA

S-Adenosyl Homocysteine
FAD
acyl- CoA dehydrogenase
H2O
Adenosine
FADH2

Methacrylyl-CoA

Tiglyl-CoA

Homocysteine
H2O
enoyl CoA hydratase
Serine
cystathionine b-synthase
ADP, AMP
H2O

3-Hydroxyisobutyryl-CoA

3-Hydroxy-2-methylbutyryl-CoA

Cystathionine
H2O
3-hydroxyisobutyryl-CoA hydrolase
NAD+
3-hydroxyacyl-CoA dehydrogenase
H2O,
cystathionine g-lyase

Threonine
CoA
NADH + H+
Cysteine, NH4+
3-Hydroxyisobutyrate

2-Methyl-3-acetoacetyl-CoA

2-oxobutanoate
treonina desidratase

AMP, ADP, valine

isoleucine, ATP

NAD+
3-hydroxyisobutyrate dehydrogenase
CoA
Acetil-CoA
Isoleucine synthesis
NADH + H+
(S)-Methylmalonate semialdehyde
methylmalonate-semialdehyde dehydrogenase

Propionyl - CoA
CO2 (HCO3-), ATP
propionyl-CoA carboxylase
(S)-Methyl-Malonyl-CoA
methylmalonyl-CoA epimerase
(R)-Methyl-Malonyl-CoA
methylmalonyl-CoA mutase

Succinyl-CoA
Homocysteine    Methionine
2-oxobutirato    Threonine
Isoleucine    Propionyl-CoA    Valine
Succinyl-CoA

Amino acids catabolism
Methionine, Threonine, Valine and Isoleucine
to Succinyl-CoA

             

Overview:

acetyl-CoA acyltransferase
SH-CoA, NAD+
NADH + H+, CO2
adenosylhomocysteinase
NH4+
ADP + Pi
DHTML JavaScript Menu Courtesy of Milonic.com