Enzyme - EC 2.5.1.6 - Methionine adenosyltransferase

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Dados da estrutura
  
Unidade biológica: Homotetrâmero
EC
  
2.5.1.6
Official Name
  
Methionine adenosyltransferase
Alternative Name(s)
 
S-adenosylmethionine synthetase.
Adomet synthetase
Class
  
2.Transferases
5.Transferring alkyl or aryl groups, other than methyl groups
Catalysed reaction
  
ATP + L-methionine + H2O phosphate + di-P + S-adenosyil-L-methionine
Substrates
  
ATP
L-methionine
H2O
Products
  
orthophosphate
Piro-P
S-Adenosyl-L-methionine
Metabolic Pathways
 
Catabolism of methionine, threonine, isoleucine and valine (3D)
Selenoamino acid metabolism (Kyoto University)
Other comments
  

S-adenosylmethionine synthetase is the enzyme that catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis.

In bacteria there is a single isoform of AdoMet synthetase, there are two in budding yeast and in mammals while in plants there is generally a multigene family. The sequence of AdoMet synthetase is highly conserved throughout isozymes and species. It has been selected two signature patterns for this type of enzyme; the first is a hexapeptide which seems to be involved in ATP-binding; the second is an almost perfectly conserved glycine-rich nonapeptide.
Reference
Expasy Molecular Information Server
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