Enzyme - EC
2.1.2.1 - Glycine hydroxymethyltransferase
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EC
2.1.2.1
Official
Name
Glycine hydroxymethyltransferase
Alternative
name(s)
Serine hydroxymethyltransferase
Serine aldolase
Threonine aldolase
Serine hydroxymethylase
Serine aldolase
Threonine aldolase
Serine hydroxymethylase
Class
2.Transferases
1.Transferring one-carbon groups
2.Hydroxymethyl-, formyl- and related transferases
1.Transferring one-carbon groups
2.Hydroxymethyl-, formyl- and related transferases
Reaction
catalysed
5,10-methylenetetrahydrofolate
+ glycine + H2O 
tetrahydrofolate
+ L-serine
tetrahydrofolate
+ L-serineSubstrates
5,10-methylenetetrahydrofolate
Acetaldehyde
4-Trimethylamoniobutanal
glycine
H2O
Acetaldehyde
4-Trimethylamoniobutanal
glycine
H2O
Products
tetrahydrofolate
L-Serine
L-threonine
3-hydroxy-N6,N6,N6-trimethyl-L-lysine
L-Serine
L-threonine
3-hydroxy-N6,N6,N6-trimethyl-L-lysine
Cofactor
PP
Metabolic
Pathways
Other
comments
Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl- L-lysine.
In vertebrates, it exists in a
cytoplasmic and a mitochondrial form whereas only one form is found in
prokaryotes. Serine hydroxymethyltransferase is a pyridoxal-phosphate
containing enzyme. The pyridoxal-P group is attached to a lysine residue
around which the sequence is highly conserved in all forms of the enzyme.
Reference