Enzyme - EC 5.3.1.1 - Triosephosphate isomerase
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Dados da estrutura
Unidade biológica: dímero
EC
5.3.1.1
Official Name
Triosephosphate isomerase
Alternative Name(s)
Triosephosphate mutas
Triose phosphoisomerase
Phosphotriose isomerase
Triose phosphoisomerase
Phosphotriose isomerase
Class
5.Isomerases
3.Intramolecular oxidoreductases
1.Interconverting aldoses and ketoses
3.Intramolecular oxidoreductases
1.Interconverting aldoses and ketoses
Catalysed reaction
D-glyceraldehyde 3-P 
glicerone-P
glicerone-PSubstrates
D-glyceraldehyde 3-P
Products
Inhibitor(s)es
2-P-glicolato
P-glicolo-hidroxamato
P-glicolo-hidroxamato
Metabolic Pathways
Other comments
2-Phosphoglycolate and phosphoglycolohydroxamate are transition state analogue/inhibitor. Crystal structures of the inhibitor complexes.
TIM plays an important role in several metabolic pathways and is essential for efficient energy production. It is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism.
The
sequence around the active site residue is perfectly conserved in all known
TIM's and can be used as a signature pattern for this type of enzyme.
Reference