Enzyme - EC 4.2.1.11 - Phosphopyruvate hydratase
 |
 |
 |
Click on the image to start downloading the PDB file (tridimensional and interactive).
EC
4.2.1.11
Official Name
Phosphopyruvate hydratase
Alternative Name(s)
Enolase
2-phosphoglycerate dehydratase
2-phosphoglycerate dehydratase
Class
4.Lyases
2.Carbon-oxygen lyases
1.Hydro-lyases
2.Carbon-oxygen lyases
1.Hydro-lyases
Catalysed reaction
2-P-D-glycerate 
phosphoenolpyruvate
+ H2O
phosphoenolpyruvate
+ H2OSubstrates
2-Phospho-D-glycerate
3-Phospho-D-erythronate
3-Phospho-D-erythronate
Products
H2O
Phosphoenol-4-deoxy-3-tetrulosonate
Inhibitor(s)
Phosphonoacetohydroxamate
Cofactor(s)
Magnesium
Metabolic Pathways
Other comments
Also acts on 3-phospho-D-erythronate.
It is a dimeric enzyme that requires magnesium both for catalysis and stabilizing the dimer. Enolase is probably found in all organisms that metabolize sugars. In vertebrates, there are three different tissue-specific isozymes: alpha present in most tissues, b in muscles and gamma found only in nervous tissues.
As a signature pattern for enolase, it has been selected the best conserved region, it
is located in the C-terminal third of the sequence.
Reference