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Fructose-1,6-bisphosphate triosephosphate-lyase
1.Carbon-carbon lyases
2.Aldehyde-lyases
glycerone-P
+ D-glyceraldehyde-3-P(3S,4R)-cetose 1-P
Sedoheptulose 1,7-bi-P
D-glyceraldehyde 3-P
D-eritrose 4-P
Also acts on (3S,4R)-ketose 1-phosphates. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
Class-I aldolase: mainly found in higher
eukaryotes, are homotetrameric enzymes which form a Schiff-base intermediate
between the C-2 carbonyl group of the substrate (dihydroxyacetone phosphate)
and the epsilon-amino group of a lysine residue.
Reference
Class-II aldolases: mainly found in prokaryotes and
fungi, are homodimeric enzymes which require a divalent metal ion generally
zinc - for their activity.
Reference