Aminoacids synthesis - glutamate, glutamine, arginine and proline

Links

NADH/ NADPH, H⁺

L-Glutamate

ATP ADP + Pi

L-Glutamine

+ NH₃

glutamate dehydrogenase

glutamate ammonia ligase

glutamate, glycerol

alanine, glycine, histidine, tryptophan, glucosamine-6-P, carbamoyl-P, CTP, AMP, glutamine, NH3

ATP

CoA

glutamate 5-kinase

amino acid acetyl-transferase

arginine

N-acetyl-glutamate

NADH/ NADPH, H+

ATP

acetyl-glutamate kinase

Arginine

NAD+/ NADP+, Pi

glutamate semialdehyde dehydrogenase

ADP

Glutamate5-semialdehyde

N-acetyl glutamyl-P

NADH/ NADPH, H+

N-acetil glutamil-P reductase

Arginine

non-enzymatic

L1-pirroline-5-carboxilate

N-acetylglutamate semialdehyde

NADH/ NADPH, H+

pirroline carboxilate reductase

ATP, ADP

acetyl-ornithine transaminase

arginine

N-2-acetylornithine

acetylornithine deacetylase

Overview:

+ NH₃

Amino acid Synthesis
Glutamate, Arginine, glutamine e proline

NAD⁺^{/
NADP+,
H₂O}

2-oxoglutarate glutamate glutamine

proline

arginine

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