Enzyme - EC 2.7.2.11 - Glutamate 5-kinase
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The tridimensional structure of this enzyme has not been resolved yet.
EC
2.7.2.11
Official Name
glutamate 5-quinase
Alternative Name(s)
g-glutamyl kinase.
Class
2.Transferases
7.Transferring phosphorus-containing groups
2.Phosphotransferases with a carboxyl group as acceptor
7.Transferring phosphorus-containing groups
2.Phosphotransferases with a carboxyl group as acceptor
Catalysed reaction
ATP + L-glutamate 
ADP
+ L-glutamate-5-P
ADP
+ L-glutamate-5-PSubstrates
ATP
L-glutamate
L-glutamate
Products
ADP
L-glutamate-5-P
L-glutamate-5-P
Metabolic Pathways
Other comments
The product rapidly cyclizes to 5-oxoproline and phosphate.
In eubacteria and yeast, GK is a monofunctional protein, while in plants and mammals, it is a bifunctional enzyme that consists of two domains: a N-terminal GK domain and a C-terminal g-glutamyl-P reductase (EC 1.2.1.41) domain.
As a signature pattern, it has been selected a highly conserved glycine-and alanine-
rich region located in the central section of these enzymes.
Reference