Enzyme - EC
1.2.1.41 Glutamate-5-semialdehyde dehydrogenase
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The tridimensional structure
of this enzyme has not been resolved yet.
EC
1.2.1.41
Official
Name
Glutamate-5-semialdehyde dehydrogenase
Alternative
name(s)
g-glutamylphosphate reductase
b-glutamylphosphate reductase
Glutamyl-g-semialdehyde dehydrogenase
b-glutamylphosphate reductase
Glutamyl-g-semialdehyde dehydrogenase
Class
1.Oxidoreductases
2.Acting on the aldehyde or oxo group of donors
1.With NAD+ or NADP+ as acceptor
2.Acting on the aldehyde or oxo group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
L-glutamate 5-semialdehyde
+ P + NADP+
L-g-glutamyl
5-P + NADPH
L-g-glutamyl
5-P + NADPHSubstrates
L-glutamate 5-semialdehyde
orthophosphate
NADP+
orthophosphate
NADP+
Products
L-Glutamyl 5-P
NADPH
NADPH
Metabolic Pathways
Other
comments
Gamma-glutamyl phosphate reductase is the enzyme that catalyzes the second step in the biosynthesis of proline from glutamate, the NADP-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5- semialdehyde and phosphate.
As a signature pattern, it has been selected a conserved region that contains two
histidine residues. This region is located in the last third of GPR.
Reference