Enzyme - EC 1.2.1.38 - N-acetyl-gamma-glutamyl-phosphate reductase
 
The tridimensional structure of this enzyme has not been resolved yet.
EC
  
1.2.1.38
Official Name
  
N-acetyl-gamma-glutamyl-phosphate reductase
Alternative name(s)
 
N-acetyl-glutamate semialdehyde dehydrogenase
NAGSA dehydrogenase
Class
  
1.Oxidoreductases
2.Acting on the aldehyde or oxo group of donors
1.With NAD+ or NADP+ as acceptor
Reaction catalysed
  
N-acetyl-L-glutamate 5-semialdehyde + NADP+ + PN-acetyl-5-glutamyl-P + NADPH
Substrates
  
N-acetyl-L-glutamate 5-semialdehyde
NADP+
Orthophosphate
Products
  
N-acetyl-5-glutamyl-P
NADPH

Metabolic Pathways

  
Synthesis of glutamine, arginine, glutamate and proline (3D)
Other comments
  

N-acetyl-gamma-glutamyl-phosphate reductase is the enzyme that catalyzes the third step in the biosynthesis of arginine from glutamate, the NADP-dependent reduction of N-acetyl-5-glutamyl phosphate into N-acetylglutamate 5-semialdehyde. In bacteria it is a monofunctional protein of 35 to 38 Kd (gene argC) while in fungi it is part of a bifunctional mitochondrial enzyme (gene ARG5,6, arg11 or arg-6) which contains a N-terminal acetylglutamate kinase (EC 2.7.2.8) domain and a C-terminal AGPR domain.

In the Escherichia coli enzyme, a cysteine has been shown to be implicated in the catalytic activity, the region around this residue is well conserved and can be used as a signature pattern.
Reference
Expasy Molecular Information Server
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