Enzyme - EC
1.8.1.4 - Dihydrolipoamide dehydrogenase
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EC
Official
Name
Dihydrolipoamide dehydrogenase
Alternative
name(s)
Lipoamide reductase (NADH)
E3 component of a-ketoacid dehydrogenase complexes
Lipoyl dehydrogenase
Dihydrolipoyl dehydrogenase
Diaphorase
Class
1.Oxidoreductases
8.Acting on a sulfur group of donors
1.With NAD+ or NADP+ as acceptor
8.Acting on a sulfur group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
Dihydrolipoamide
+ NAD+ 
Lipoamide
+ NADH
Lipoamide
+ NADHSubstrates
Dihydrolipoamide
Methylene blue
NAD+
Methylene blue
NAD+
Products
Lipoamide
NADH
NADH
Cofactor
FAD
Metabolic
Pathways
Citrate Cycle (3D)
Catabolism of isoleucine, leucine and tryptophan (3D - isoleucine, leucine e tryptophan)
Lysine and tryptophan catabolism (3D)
Catabolism of isoleucine, leucine and tryptophan (3D - isoleucine, leucine e tryptophan)
Lysine and tryptophan catabolism (3D)
Other
comments
Component of the multienzyme pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase complex.
This enzyme was first shown to catalyse the oxidation of NADH by methylene blue; this activity was called diaphorase.
Belongs to the group of pyridine nucleotide-disulphide oxidoreductases.