Enzyme - EC 3.5.1.2 - glutaminese
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The tridimensional structure of this enzyme has not been resolved yet.
EC
3.5.1.2
Official Name
glutaminese
Alternative Name(s)
L-glutamine amidohydrolase
Class
3.Hydrolases
5.Acting on carbon-nitrogen bonds, other than peptide bonds
1.In linear amides
5.Acting on carbon-nitrogen bonds, other than peptide bonds
1.In linear amides
Catalysed reaction
L-glutamine + H2O 
L-glutamate
+ NH3
L-glutamate
+ NH3Substrates
L-glutamine
H2O
H2O
Products
NH3
Metabolic Pathways
Other comments
Asparaginase(EC
3.5.1.1), glutaminase (EC 3.5.1.2) and glutaminese-asparaginase(EC
3.5.1.38) are aminohydrolases that catalyze the hydrolysis
of asparagine (or glutamine) to aspartate (or glutamate) and ammonia.
Two conserved threonine residues have been shown to play a catalytic
role. One of them is located in the N-terminal extremity while the second is
located at the end of the first third of the sequence. Both
conserved regions has been used as signature patterns.
Reference