Enzyme - EC 3.5.1.1 - asparaginase
 |
 |
 |
Click on the image to start downloading the PDB file (tridimensional and interactive).
EC
3.5.1.1
Official Name
asparaginase
Alternative Name(s)
L-asparaginase
L-asparagine amidohydrolase
L-asparagine amidohydrolase
Class
3.Hydrolases
5.Acting on carbon-nitrogen bonds, other than peptide bonds
1.In linear amides
5.Acting on carbon-nitrogen bonds, other than peptide bonds
1.In linear amides
Catalysed reaction
L-asparagine + H2O 
L-aspartate
+ NH3
L-aspartate
+ NH3Substrates
L-asparagine
H2O
H2O
Products
NH3
Metabolic Pathways
Other comments
Asparaginase(EC
3.5.1.1), glutaminase(EC 3.5.1.2) and glutaminese-asparaginase(EC 3.5.1.38)
are aminohydrolases that catalyze the hydrolysis
of asparagine (or glutamine) to aspartate (or glutamate) and ammonia.
Two conserved threonine residues have been shown to play a catalytic
role. One of them is located in the N-terminal extremity while the second is
located at the end of the first third of the sequence. Both
conserved regions has been used as signature patterns.
Reference