Enzyme - EC 3.5.4.4 - adenosine deaminase
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EC
3.5.4.4
Official Name
adenosine deaminase
Alternative Name(s)
adenosine aminohydrolase
Class
3.Hydrolases
5.Acting on carbon-nitrogen bonds, other than peptide bonds
4.In cyclic amidines
5.Acting on carbon-nitrogen bonds, other than peptide bonds
4.In cyclic amidines
Catalysed reaction
adenosine + H2O 
inosine
+ NH3
inosine
+ NH3Substrates
adenosine
H2O
H2O
Products
NH3
Inhibitor(s)
Nebularine
Metabolic Pathways
Other comments
Adenosine deaminase (EC 3.5.4.4) catalyzes the hydrolytic deamination of adenosine into inosine. AMP deaminase (EC 3.5.4.6) catalyzes the hydrolytic deamination of AMP into IMP. It has been shown that these two types of enzymes share three regions of sequence similarities; these regions are centered on residues which are proposed to play an important role in the catalytic mechanism of these two enzymes. We have selected one of these regions, it contains two conserved aspartic acid residues that are potential active site residues.
Reference