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4.Glycosyltransferases
2.Pentosyltransferases
thymine
+ 2-deoxy-D-ribose 1-Portho-P
2-Deoxy-D-ribose 1-P
In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6.
Thymidine phosphorylase catalyzes the reversible phosphorolysis
of thymidine, deoxyuridine and their analogues to their respective bases and
2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine
and is therefore essential to nucleic acid metabolism. In Escherichia coli, the enzyme is a dimer of identical subunits
of about 48 Kd. In humans it was first identified as platelet-derived
endothelial cell growth factor before being recognized as
thymidine phosphorylase. Bacterial pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) is
an enzyme evolutionary and structurally related to thymidine phosphorylase. As a signature pattern for these enzymes, it has been selected a well conserved region
of 19 residues located in the N-terminal part of these proteins.
Reference