Enzyme - EC 2.4.2.2 - Pyrimidine-nucleoside phosphorylase
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EC
2.4.2.2
Official Name
Pyrimidine-nucleoside phosphorylase
Alternative Name(s)
--
Class
2.Transferases
4.Glycosyltransferases
2.Pentosyltransferases
4.Glycosyltransferases
2.Pentosyltransferases
Catalysed reaction
Pyrimidine nucleoside + P 
Pyrimidine
+ a-D-ribose 1-P
Pyrimidine
+ a-D-ribose 1-PSubstrates
Pyrimidine nucleoside
ortho-P
ortho-P
Products
Pyrimidine
a-D-ribose 1-P
a-D-ribose 1-P
Metabolic Pathways
Other comments
Thymidine phosphorylase catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism.
In Escherichia coli, the enzyme is a dimer of identical subunits
of about 48 Kd. In humans it was first identified as platelet-derived
endothelial cell growth factor before being recognized as
thymidine phosphorylase.
Reference