Enzyme - EC
1.1.1.49 - Glucose-6-phosphate 1-dehydrogenase
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EC
1.1.1.49
Official
Name
Glucose-6-phosphate 1-dehydrogenase
Alternative
name(s)
G6PD
Class
1.Oxidoreductases
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
D-Glucose 6-P
+ NADP+ 
D-glucono-1,5-lactone
6-P + NADPH
D-glucono-1,5-lactone
6-P + NADPHSubstrates
Glucose 6-P
b-D-Glucose
NADP+
NAD+
b-D-Glucose
NADP+
NAD+
Products
D-glucono-1,5-lactone
6-P
NADPH
NADH
NADPH
NADH
Inhibitor
Fatty acids
Metabolic
Pathways
Other
comments
Also acts slowly on beta-D-glucose and other sugars. Certain preparations also reduce NAD+ as well as NADP+.
Glucose-6-phosphate dehydrogenase catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate.
A lysine residue has been identified as a
reactive nucleophile associated with the activity of the enzyme. The sequence
around this lysine is totally conserved from bacterial to mammalian G6PD's and
can be used as a signature pattern.
Reference