Enzyme - EC
1.1.1.44 - Phosphogluconate dehydrogenase
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EC
1.1.1.44
Official
Name
Phosphogluconate dehydrogenase
Alternative
name(s)
6-phosphogluconic dehydrogenase
6-phosphogluconic carboxylase
6PGD
6-phosphogluconic carboxylase
6PGD
Class
1.Oxidoreductases
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
6-P-D-gluconate
+ NADP+
D-ribulose 5-P + CO2 + NADPH
D-ribulose 5-P + CO2 + NADPHSubstrates
6-P-D-gluconate
NADP+
NAD+
NADP+
NAD+
Products
D-Ribulose 5-P
CO2
NADPH
NADH
CO2
NADPH
NADH
Cofactor(s)
Metabolic
Pathways
Other
comments
Certain preparations reduce NAD+ as well as NADP+.
6-phosphogluconate dehydrogenase catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic
and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence
are highly conserved. As a signature pattern, it was selected a region
which has been shown, from studies of the sheep 6PGD tertiary structure,
to be involved in the binding of 6-phosphogluconate.
Reference