Strategy
2
Phosphatidylcholine
and phosphatidylethanolamine synthesis in mammals
phospholipds
and fatty acids
CTP, phosphocholine
phospholipds
and fatty acidsCTP, phosphocholine
Cardiolipin and Phosphatidylinositol synthesis in eucaryotics
Strategy 1
Head Group is activated
Estratégia
2
Diacylglycerol is activated
Diacylglycerol is activated
(Note
that in both cases CDP is the source of the phosphodiester bond phosphate.)
Strategy
1
Phospholipis
synthesis in E. coli
R1-CO-CoA
R2-CO-CoA
Phosphodiester
bond synthesis
Phospholipids
Synthesis
(from Glycerol and Fatty acids)
(from Glycerol and Fatty acids)
CDP-Diacylglycerol synthesis