Lipids Catabolism
Dietary lipids digestion, absorption and transport follow this scheme: |
Small intestine | intestinal mucosa cells | lymph system | blood-stream | adipose tissue cells | blood-stream | cells that need energy |
![]() |
1- Complex lipids (phospholipids and triacylglycerols) are degraded by pancreatic lipases and phospholipases in the small intestine. |
|
2-The lipid digestion products absorbed by the intestinal mucosa are converted by these tissues to triacylglycerols and |
|
3- the packaged into lipoprotein particles called chylomicrons. |
|
4- The chylomicrons, in turn, are released into the bloodstream via the lymph system for delivery to the tisuues. |
|
5- The triacilglycerol components of chylomicrons are hydrolyzed to free fatty acids and glycerol in the capillaries of adipose tissue and skeletal muscle by lipoprotein lipase. |
|
6- The resulting free fatty acids are taken up by these tissues, |
|
7- and converted to triacylglycerols in adipose tissues as energy storage. |
|
8- Mobilization of triacylglycerols stored in adipose tisuue involves their hydrolysis to glyceroll and free fatty acids by hormone-sensitive triacylglycerol lipase. |
|
10- where they bind to albumin (avoiding them to form micelles that acts as detergents to disrupt protein and membrane structure). |
|
12- Once in the cells cytosol, the fatty acids must be activated before its catabolism. |
|