Enzyme - EC 6.3.4.4 - Adenylosuccinate synthase
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Dados da estrutura
Unidade biológica: dímero
EC
6.3.4.4
Official Name
Adenylosuccinate synthase
Alternative Name(s)
Adenylosuccinate synthetase.
IMP-aspartate ligase.
Succinoadenylic kinosynthetase
IMP-aspartate ligase.
Succinoadenylic kinosynthetase
Class
6.Ligases
3.Forming carbon-nitrogen bonds
4.Other carbon--nitrogen ligases
3.Forming carbon-nitrogen bonds
4.Other carbon--nitrogen ligases
Catalysed reaction
GTP + IMP + L-aspartate 
GDP
+ P + adenyl-succinate
GDP
+ P + adenyl-succinateSubstrates
GTP
IMP
L-aspartate
IMP
L-aspartate
Products
ortho-P
N6-(1,2-Dicarboxyetil)-AMP
Metabolic Pathways
Other comments
Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle.
As signature patterns, it were selected selected two conserved regions. The first one is
a perfectly conserved octapeptide located in the N-terminal section and which
is involved in GTP-binding. The second one includes a lysine residue known to be essential for the enzyme's activity.
Reference