Enzyme - EC 6.3.4.13 - Phosphoribosylamine-glycine ligase
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EC
6.3.4.13
Official Name
Phosphoribosylamine-glycine ligase
Alternative Name(s)
Phosphoribosylglycinamide synthetase
Glycinamide ribonucleotide synthetase
GAR synthetase
GARS
Glycinamide ribonucleotide synthetase
GAR synthetase
GARS
Class
6.Ligases
3.Forming carbon-nitrogen bonds
4.Other carbon--nitrogen ligases
3.Forming carbon-nitrogen bonds
4.Other carbon--nitrogen ligases
Catalysed reaction
ATP + 5-P-D-ribosylamine + glycine 
ADP
+ P + N(1)-(5-P-D-ribosyl)glycinamide
ADP
+ P + N(1)-(5-P-D-ribosyl)glycinamideSubstrates
ATP
5-P-D-ribosylamine
glycine
5-P-D-ribosylamine
glycine
Products
ortho-P
N1-(5-P-D-ribosyl)glycinemide
Metabolic Pathways
Other comments
In bacteria GARS is a monofunctional enzyme, in yeast it is part, with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) of a bifunctional enzyme in higher eukaryotes it is part, with AIRS and with phosphoribosylglycinamide formyltransferase (GART) of a trifunctional enzyme (GARS-AIRS-GART).
The sequence of GARS is well conserved. As a signature pattern we selected a
highly conserved octapeptide.
Reference