Enzyme - EC 6.3.2.6 - Phosphoribosylaminoimidazole-succinocarboxamide synthase
 |
 |
 |
Click on the image to start downloading the PDB file (tridimensional and interactive).
EC
6.3.2.6
Official Name
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Alternative Name(s)
SAICAR synthase
Class
6.Ligases
3.Forming carbon-nitrogen bonds
2.Acid--amino-acid ligases (peptide synthases)
3.Forming carbon-nitrogen bonds
2.Acid--amino-acid ligases (peptide synthases)
Catalysed reaction
ATP + 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
+ L-aspartate 
ADP
+ P + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
ADP
+ P + 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazoleSubstrates
ATP
1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
L-aspartate
1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
L-aspartate
Products
ortho-P
1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
Metabolic Pathways
Other comments
In bacteria, fungi and plants, SAICAR synthetase is a monofunctional protein; in higher vertebrates it is the N-terminal domain of a bifunctional enzyme that also catalyze phosphoribosylaminoimidazole carboxylase (AIRC) activity.
As signature patterns for SAICAR synthetase, it were selected two conserved regions
in the central section of this enzyme.
Reference