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Phosphoglucose mutase
4.Intramolecular transferases (mutases)
2.Phosphotransferases (phosphomutases)
a-D-glucose
6-Pa-D-Hexose 1-P
a-D-Ribose 1-P
a-D-Hexose 6-P
a-D-Ribose 5-P
Maximum activity is only obtained in the presence of a-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate.
The catalytic mechanism involves the formation of a
phosphoserine intermediate. The sequence around the serine residue is well
conserved and can be used as a signature pattern.
Reference