Enzyme - EC 4.2.99.9 - O-succinylhomoserine (thiol)-lyase
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EC
4.2.99.9
Official Name
O-succinylhomoserine (thiol)-lyase
Alternative Name(s)
Cystathionine g-synthase
Class
Liases - Liases de ligações
C-O - Carbono-oxigênio liases
Catalysed reaction
O-succinyl-L-homoserine + L-cysteine
cystathionine
+ succinate
cystathionine
+ succinateSubstrates
O-Succinyl-L-homoserine
L-Cysteine
Hydrogen sulfide
Methanethiol
L-Cysteine
Hydrogen sulfide
Methanethiol
Products
Succinate
L-Homocysteine
Methionine
2-Oxobutanoate
NH3
Cofactor(s)
pyridoxal-P
Metabolic Pathways
Other comments
Can also use hydrogen sulfide and methanethiol as substrates producing homocysteine and methionine respectively. In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
RElated to others Cys/Met metabolism enzymes pyridoxal-phosphate.