Enzyme - EC 4.2.1.19 - Imidazoleglycerol-phosphate dehydratase
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The tridimensional structure of this enzyme has not been resolved yet.
EC
4.2.1.19
Official Name
Imidazoleglycerol-phosphate dehydratase
Alternative Name(s)
--
Class
4.Lyases
2.Carbon-oxygen lyases
1.Hydro-lyases
2.Carbon-oxygen lyases
1.Hydro-lyases
Catalysed reaction
D-erythro-1-(imidazol-4-il)glycerol 3-P
3-(imidazol-4-il)-2-oxopropil-P
+ H2O
3-(imidazol-4-il)-2-oxopropil-P
+ H2OSubstrates
D-erythro-1-(imidazol-4-il)glycerol 3-P
Products
H2O
Metabolic Pathways
Other comments
Imidazoleglycerol-phosphate dehydratase is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. In most organisms it is a monofunctional protein of about 22 to 29 Kd. In some bacteria such as Escherichia coli it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain.
Two signature patterns were developed, each include two consecutive
histidine residues.
Reference