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The tridimensional structure of this enzyme has not been resolved yet.
7.Transferring phosphorus-containing groups
2.Phosphotransferases with a carboxyl group as acceptor
ADP
+ 4-P-L-aspartateL-aspartate
4-P-L-aspartate
The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. In this bacteria there are three different isozymes which differ in their sensitivity to repression and inhibition by Lysine, Methionine and Threonine.
Aspartokinase catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine.
As a signature pattern for AK, it has been selected a conserved region located in the
N-terminal extremity.
Reference