Enzyme - EC 2.5.1.21 - Farnesyl-diphosphate farnesyltransferase
 |
 |
 |
Click on the image to start downloading the PDB file (tridimensional and interactive).
EC
2.5.1.21
Official Name
Farnesyl-diphosphate farnesyltransferase
Alternative Name(s)
Farnesyltransferase
Presqualene-di-diphosphate synthase
Squalene synthase
Presqualene-di-diphosphate synthase
Squalene synthase
Class
2.Transferases
5.Transferring alkyl or aryl groups, other than methyl groups
5.Transferring alkyl or aryl groups, other than methyl groups
Catalysed reaction
2 farnesyl di-P 
di-P
+ Presqualene di-P
di-P
+ Presqualene di-PSubstrates
Farnesyl diphosphate
Presqualene diphosphate
NADPH
Cyclopropylcarbinyl cation
Presqualene diphosphate
NADPH
Cyclopropylcarbinyl cation
Products
Pyrophosphate
Presqualene diphosphate
Cyclopropylcarbinyl cation
NADP+
Squalene
Presqualene diphosphate
Cyclopropylcarbinyl cation
NADP+
Squalene
Inhibitor(s)
a-Phosphono sulfonate triacid
Metabolic Pathways
Other comments
The polymeric form of the enzyme also catalyses the reduction of
presqualene diphosphate by NADPH to squalene via cationic
intermediate, cyclopropylcarbinyl cation, which was trapped as
the corresponding alcohol, rillingol, by using a dihydro analog of
NADPH as the reducing agent.
One of the two polyisoprene synthases.