Enzyme - EC 2.4.2.12 - Amidophosphoribosyltransferase
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EC
2.4.2.12
Official Name
Amidophosphoribosyltransferase
Alternative Name(s)
Glutamine phosphoribosylpyrophosphate amidotransferase
Phosphoribosyldiphosphate 5-amidotransferase
Phosphoribosyldiphosphate 5-amidotransferase
Class
2.Transferases
4.Glycosyltransferases
2.Pentosyltransferases
4.Glycosyltransferases
2.Pentosyltransferases
Catalysed reaction
5-P-b-D-ribosylamine
+ di-P + L-glutamate 
L-glutamine
+ 5-P-a-D-ribose-1-di-P + H2O
L-glutamine
+ 5-P-a-D-ribose-1-di-P + H2OSubstrates
5-P-b-D-ribosylamine
Piro-P
L-glutamate
Piro-P
L-glutamate
Products
L-glutamine
5-P-a-D-ribose-1-di-P
H2O
5-P-a-D-ribose-1-di-P
H2O
Metabolic Pathways
Other comments
Belongs to the purine/pyrimidine phosphoribosyl transferases signature.
It's able to catalyze the removal of the
ammonia group from glutamine and then to transfer this group to a substrate to
form a new carbon-nitrogen group (Glutamine amidotransferases class-II active site).