Enzyme - EC
1.7.3.3 - Urate oxidase
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EC
1.7.3.3
Official
Name
Urate oxidase
Alternative
name(s)
Uricase
Class
Oxidoredutases
atuando sobre compostos nitrogenados dos doadores, com o oxigênio
como acceptor.
Reaction
catalysed
Urate + O2
+ H2O 
5-hydroxyisourate + H2O2
5-hydroxyisourate + H2O2Substrates
Urate
O2
O2
Products
Unidentified products (5-hydroxyisourate decompose to form allantoin)
Cofactor
Copper
Metabolic
Pathways
Other
comments
5-hydroxyisourate decompose to form allantoin.
Uricase is the peroxisomal enzyme responsible for the degradation of urate into allantoin. Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate.
Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved
and it has been used, as a signature pattern, a highly conserved region located
in the central part of the sequence.
Reference