Enzyme - EC
1.3.99.11 - Dihydroorotate dehydrogenase
 |
 |
The tridimensional structure
of this enzyme has not been resolved yet.
EC
1.3.99.11
Official
Name
Dihydroorotate dehydrogenase
Alternative
name(s)
--
Class
1.Oxidoreductases
3.Acting on the CH-CH group of donors
99.With other acceptors
3.Acting on the CH-CH group of donors
99.With other acceptors
Reaction
catalysed
(S)-Dihydroorotate
+ acceptor 
orotate
+ reduced acceptor
orotate
+ reduced acceptorSubstrates
(S)-Dihydroorotate
acceptor
O2
2,6-Dichloroindophenol
1,10-Phenanthroline
acceptor
O2
2,6-Dichloroindophenol
1,10-Phenanthroline
Products
orotate
reduced acceptor
H2O
2,6-Dichlorophenol-4-(p-benzoquinone imine)
reduced acceptor
H2O
2,6-Dichlorophenol-4-(p-benzoquinone imine)
Cofactors
Iron;
Zinc
Metabolic
Pathways
Other
comments
An iron-zinc protein. Oxygen can act as acceptor, but much more slowly than 2,6-dichloroindophenol or 1,10-phenanthroline.