Enzyme - EC
1.1.1.205 - IMP dehydrogenase
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EC
1.1.1.205
Official
Name
IMP dehydrogenase
Alternative
name(s)
Inosine-5'-monophosphate
dehydrogenase
Inosinic acid dehydrogenase
Inosinate dehydrogenase
IMP oxidoreductase
Inosine monophosphate oxidoreductase
Inosinic acid dehydrogenase
Inosinate dehydrogenase
IMP oxidoreductase
Inosine monophosphate oxidoreductase
Class
1.Oxidoreductases
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
1.Acting on the CH-OH group of donors
1.With NAD+ or NADP+ as acceptor
Reaction
catalysed
Inosine 5'-P
+ NAD+ + H2O
Xanthosine
5'-P + NADH
Xanthosine
5'-P + NADHSubstrates
Inosine 5'-P
NAD+
H2O
NAD+
H2O
Products
Xanthosine 5'-P
NADH
NADH
Metabolic Pathways
Other
comments
The enzyme acts on the hydroxyl group of the hydrated derivative of the substrate.
IMP dehydrogenase catalyzes the rate-limiting reaction of de novo GTP biosynthesis, the NAD-dependent reduction of IMP into XMP. Inhibition of IMP dehydrogenase activity results in the cessation of DNA synthesis. As IMP dehydrogenase is associated with cell proliferation, it is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans.